The proton-pump inhibitors esomeprazole (nexium 24hr), lansoprazole (prevacid 24hr), and omeprazole (prilosec otc) are sold over-the-counter to treat frequent heartburn (two or more times per week. Best acid reflux medication otc. The best over-the-counter medicine treatments for severe acid reflux, also known as heartburn, are antacids, acid blockers and proton pump inhibitors, states webmd maalox, rolaids and tums are popular antacid brands; pepcid, zantac and axid are examples of over-the-counter acid blockers prilosec is an example of a proton pump inhibitor.
best acid reflux medication otc